After taking the lead through Memphis Depay, Louis van Gaal's side crumbled against their Danish opponents. Sisto equalised for the home side just before half-time before Paul Onuachu struck the winner.
It was arguably the lowest point of Van Gaal's reign at Old Trafford and a result that left the travelling fans furious.
Video footage has emerged which shows supporters repeatedly chanting "We're f****** s***" at the Manchester United players after the full-time whistle. The chants continued despite some of the players moving towards the away section and clapping in a show of appreciation for those who had made the trip.
WARNING: VIDEO BELOW CONTAINS BAD LANGUAGE...
Another video filmed at the MCH Arena shows away support being less than enthusiastic about their own side. Fans can be heard singing: "Oh what a night, freezing cold on a Thursday night and we're playing f****** s****".
WARNING: VIDEO BELOW CONTAINS BAD LANGUAGE...
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Some of the Manchester United fans who made the trip to Denmark were already angry due to the ticket prices imposed by Midtjylland. Despite charging supporters £22 when they played Southampton earlier in the season, United fans had to fork out £71 to watch their team.
The second leg at Old Trafford will be played next Thursday.
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